My only concern is prostate problems.. Please make sure you don't have problems with it before begin the cycle.
Rest, i did many high dose primo cycles. And I believe using it 300-400 mg is just a waste..
I did 800 mg / week many times.. i believe you start to see real results of primo on 500mg+/week and it become really fun at 800 mg. If you want to use it, i'd start somewhere 500-600/week..
I never run it at 1g/week. ..